Specialty pharmacy benefit — both Ionis products are self-injected, specialty-only
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600 patients today
2 updatesJun 1, 2026 May 18, 2026
The Cigna Group · PBM: Express Scripts · National
Cigna Healthcare
Accredo-exclusive dispensing for both Ionis products. Prior-prophylaxis step documented for HAE.
CommercialMedicare Part D
Live from the coverage database
Policy Posture and UM Criteria by Indication
| INDICATION | STATUS | PUBLISHED CRITERIA | AUTH DURATION | EFFECTIVE | SOURCE | CONFIDENCE |
|---|---|---|---|---|---|---|
| Tryngolza (FCS) | Published — Restricted | Prior authorization required. Initial approval requires prescribing by or in consultation with a specialist in the condition. Extensive documentation required (chart notes, labs, genetic test results). | Not specified in summary | 2025-06-15 | Coverage Policy IP0733 - Tryngolza | Sourced |
Coverage Update YTD
8Across all sources
Treated Lives — Tryngolza (FCS)
600Patients on therapy
Ionis Brands Published
1 / 3Have a policy
Pending Policy Changes
1Next 30 days
Months since launch · illustrative
Treated Lives on Therapy — Tryngolza (FCS)
M1 · 48M4 · 144M8 · 270M12 · 396M18 · 510M24 · 600
50-state distribution · illustrative
Treated Lives by State — Tryngolza (FCS)
Fewer patientsMore patients
NV high
AI SUMMARY
Tryngolza — FCS Coverage Source Summary
No FCS activity logged yet at Cigna — Accredo-exclusive dispensing is expected to apply once a policy is issued.
Historical coverage trend
Tryngolza — FCS Lives Coverage Trend
% of lives by access status across historical snapshots.
CoveredPreferredNot coveredUnknown
Covered
92%+81 pts
Preferred
78%+70 pts
Not covered
8%-12 pts
Unknown
32%+23 pts
Latest source details
Tryngolza — FCS Coverage Details
3 source views
| Source | Payment Type | Policy Status | Latest Detail |
|---|---|---|---|
| MMIT Searchlight | Commercial | Published — Restricted | Syndicated data reflects the most recent policy language for this indication. |
| FRM submission | Medicare | Limited visibility | Field team confirms account-level nuance not yet captured in syndicated sources. |
| Market Access submission | Medicaid | Limited visibility | State/plan-level detail requires validation against current directories. |
Brand-specific feed
Latest Updates
MMIT Searchlight
Latest source refresh confirms no material change to published criteria this cycle.
FRM submission
Field notes on account-level access nuance submitted for validation.
Brand documents
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Policy PDF
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Latest updated: Jun 1, 2026